Ms. Meyammai Shanmugham from FRG Team (a.k.a Mey), won the third prize in the Best Oral Presentation Award in Monash Initiate 2022, Monash International Health Science and Technology Conference. This conference was held virtually to provide a platform for researchers, academics, and students globally to communicate their research findings. Mey is a PhD student from SUTD, supervised by Dr. Leo Chen Huei and Dr. Liu Xiaogang. At this conference, she presented her paper titled, Time-dependent Activation of TMAO Induced Apoptosis and Inflammation on Human Microvascular Endothelial Cells (HMEC-1). In this work, she analyzed the time-dependent molecular signatures of TMAO treatment on HMEC-1. The findings of her study indicate how TMAO induces endothelial dysfunction, and it provides potential therapeutics to directly target the damages induced by TMAO at the appropriate duration for treatment intervention.
We are happy to share that Xiaogang received Shimadzu-SNIC Industry Award in Applied and Translational Chemistry in Jun 2022. The SNIC industry awards recognise and reward outstanding individuals, who have achieved research excellence in selected areas of chemistry and chemical sciences.
Xiaogang received this award for his work in establishing the structure-property relationships of fluorescent dyes and probes and formulating efficient prediction methods for developing functional fluorophores.
This achievement is the results of the collective work of all FRG members! So of course, the entire team had a good lunch at Changi City Point to celebrate!
FRG Team won the 2nd Runner-Up Prize in the HPC Innovation Challenge for the Environment competition in September 2022!
This competition intends to explore how we can tackle environmental challenges using High-Performance Computing (HPC). The FRG team, consisting of Miss Wu Xia and Mr. Shen Tianruo, focused on the computation-aided design of “small“ and ”red“ fluorophores (namely ‘Singapore Red”) for bioimaging and biosensing applications. Their computational design minimizes ‘trial-and-error’ in experimental synthesis and thereby reduces waste generation during the development of chemical products. This design-centric approach offers a new route to greening chemical synthesis and reducing carbon emissions and waste discharge to the environment. Continue reading
Our review article, Twisted intramolecular charge transfer (TICT) and twists beyond TICT: from mechanisms to rational designs of bright and sensitive fluorophores, was published in the journal of Chemical Society Reviews! This work was completed in collaboration with Zhaochao Xu group from the Dalian Institute Chemical Physics. It focused on the structure-property relationships of TICT fluorophores, and summarised design guidelines for tuning the tendency of TICT and modulating the fluorescence of these molecules.
We are glad to share that this review was featured in EurekaAlert! And ScienMag. FRG congratulates Dr. Wang Chao and team for this news!
American Chemical Society (ACS) on Campus hosted their first-ever digital event at Singapore University of Technology and Design (SUTD). Prof. Xiaogang Liu delivered an interesting speech on Effective Writing Skills. The feedback was very positive and the audience learned the basic skills to write a technical article in the correct manner. Find out more at: https://axial.acs.org/2021/11/24/acs-on-campus-sutd/.
FRG congratulates Tianruo for the completion of his master’s degree. He did an excellent work over his master studies. We now welcome him to join our group as a PhD student.
The State-crossing from a Locally Excited to an Electron Transfer State(SLEET) model has been applied to rationalize the mechanism of Aggregation-Induced Emission(AIE). CRCU Journal highlighted it on their cover page of the journal. Congratulations to Weijei and Chao for this tremendously rewarding accomplishment!
Our UROP Project work was featured by C&EN and ACS Central Science!
“Xiaogang Liu is using fluorescence to tackle the problem of illicit cooking oil. The Singapore-based physical chemist is building a database of fluorescence fingerprints to help nab adulterated food products”.
The fluorescence fingerprint of extra virgin olive oil (left) changes after heating for 1 h at 200 °C (right). Credit: Courtesy of Xiaogang Liu
We have developed a theoretical descriptor ΔE for predicting PET-based fluorescence probes; utilizing this descriptor, we quantitatively designed fluorescent stains of lipid droplets and mitochondria for live-cell bioimaging.
This work was published in JACS, and reported by various mediums, such as:
Supphachok Chanmungkalakul (aka “Earth”) won a prestigious research award from the National Research Council of Thailand in Feb 2020, for the work done during his Master studies.
Earth joined the Fluorescence Research group in Jan 2020. He will work on research under the theme of luminescence in organic compounds. Welcome, Earth!